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4 edition of Regulation of cell-cell communication and growth in normal and neoplastic cells found in the catalog.

Regulation of cell-cell communication and growth in normal and neoplastic cells

Che-wei Ou

Regulation of cell-cell communication and growth in normal and neoplastic cells

  • 87 Want to read
  • 29 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1994.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL17042172M
ISBN 100315963549
OCLC/WorldCa222158905

lar communication between tumour cells and other cells is accom-plished via cell-cell interactions. Tumour cell released growth factors, chemokines, proteins, mRNAs, microRNAs, etc., are carried and transferred by carriers. Exosomes may serve as important molecular information carriers to communicate with CSCs, non-CSCs and other. - are the cells that form the 3 germinal layers of the embryo. - ES cells can produce all the different cells / tissues of the body, thus called totipotent (note: pluripotent refers to cells that can become some or many different cell types). - may be able to use ES cells in a procedure called “therapeutic cloning” to repair damaged organs. Negative regulation of N-cadherin-mediated cell-cell adhesion by the estrogen receptor signaling pathway in rat pituitary GH3 cells. Endocrine 10(1): Lail-Trecker M, Gulati R, Peluso JJ. A role for hepatocyte growth factor/scatter factor in regulating normal and neoplastic cells .


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Regulation of cell-cell communication and growth in normal and neoplastic cells by Che-wei Ou Download PDF EPUB FB2

Extracellular matrix regulation of cell-cell communication and tissue-specific gene expression in primary liver cultures.

on the growth and differentiation of normal and neoplastic liver cells. Currently we are focused on analyzing the influence of the extracellular matrix components, glycosaminoglycans and proteoglycans.

which induced Cited by:   Extracellular matrix regulation of cell-cell communication and tissue-specific gene expression in primary liver cultures. on the growth and differentiation of normal and neoplastic liver cells.

Currently we are focused on analyzing the influence of the extracellular matrix components, glycosaminoglycans and proteoglycans. on the growth Cited by: Neoplastic and Normal Cells in Culture independent growth enhancement in MuMTV-infected cells is followed by expression of a cell-surface antigen, recognized by allogeneic (C3HAKR) anti.

Craig A. Peters, in Pediatric Urology, Growth Regulation. Growth regulation determines the number of cells, the number of glomeruli, and the length of tubules or collecting ducts. Growth is the balance between cell proliferation and cell death (apoptosis), a tightly regulated dynamic in the developing kidney, and obstruction clearly affects this in all segments of the nephron.

Regulation of the Cell Cycle in Normal and Neoplastic Cells study guide by jxe includes 55 questions covering vocabulary, terms and more. Quizlet flashcards, activities and games help you improve your grades.

For example, hematopoetic stem cells in the bone marrow can divide and give rise to progenitor cells that can differentiate into cellular element of blood and the immune system, including red blood cells, lymphocytes, neutrophils, eosinophils, basophils, monocytes, and platelets.

Bone marrow stromal stem cells (also called mesenchymal stem cells, or skeletal stem cells) can generate bone. Science AP®︎/College Biology Cell communication and cell cycle Regulation of cell cycle. Cancer and the cell cycle. : IST‑1 (EU), IST‑1.D (LO), Practice: Regulation of cell cycle. Sort by: Top Voted.

Loss of cell cycle control in cancer. Regulation of cell cycle. Up Next. Learn how cells communicate with one another using different kinds of short- and long-range signaling in our bodies.

Cell communication. Next lesson. Signal transduction. Sort by: Top Voted. Overview of cell signaling. Cell-cell signaling in unicellular organisms. Up Next. Cell-cell signaling in unicellular organisms. Biology is brought to.

• Neoplasia- new growth – Abnormal mass of tissue with growth that exceeds and is uncoordinated with that of the surrounding normal tissues; autonomous • Tumor- synonymous with neoplasm • Cancer- common term for malignant neoplasm •N eoplasms have parenchymaand stroma • Benign and malignant tumors each have their own nomenclature.

Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network.

Two MAP kinase (MAPK) pathways are essential for communication and cell fusion in N. crassa: the cell wall integrity/MAK-1. A form of leukaemia characterised by the increased and unregulated growth of predominantly myeloid cells in the BM and the accumulation of these in the blood.

It is characterised by the abnormal chromosomal translocation called the Philadelphia Chromosome. Key Difference – Cancer Cell Cycle vs Normal Cell Cycle. The cell cycle is the series of events that take place in the cell, leading to its division and duplication of DNA in order to produce new daughter cells.

The cell cycle can be observed in both bacteria and bacteria, cell cycle consists of three phases (B, C, and D). Multicellular organisms depend on cell-to-cell communication to coordinate both development and environmental responses across diverse cell types.

Intercellular signaling is particularly critical in plants because development is primarily postembryonic and continuous over a plant’s life span. Additionally, development is impacted by restrictions imposed by a sessile lifestyle and limitations. Abstract. In this chapter, we will describe some of the molecular mechanisms involved in the control of normal cell growth.

In addition we will discuss abnormalities in these mechanisms which are found in neoplastic cells, and which may be active in carcinogenesis. A cell grows and carries out all normal metabolic functions and processes in a period called G1 (Figure ). G1 phase (gap 1 phase) is the first gap, or growth phase in the cell cycle.

For cells that will divide again, G1 is followed by replication of the DNA, during the S phase. Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant sites.

The crosstalk between neoplastic cells and accessory elements, such as immune and stromal cells, fosters several processes that are necessary for tumor progression and. We show that this growth inhibition is contingent on the presence of junctional communication between the normal and transformed cells (heterologous communication), as probed with a dalton.

During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment.

The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has. Immunophenotype of Neoplastic Plasma Cells.

Plasma cells (normal and neoplastic) express CD38(bright) and CD CD is more specific but less sensitive. Normal peripheral blood plasma cells are CD45 +. In bone marrow, there are two subsets of plasma cells: one major subset positive for CD45 and a smaller negative one.

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances.

There are two kinds of communication in the world of living cells. Communication between cells is called intercellular signaling, and communication within a cell is called intracellular easy way to remember the distinction is by understanding the Latin origin of the prefixes: inter- means "between" (for example, intersecting lines are those that cross each other) and intra- means.

The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth.

The following topics were closely related to the theme of the workshops: 1. To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively).

Flow cytometry and mammosphere assays revealed that in murine breast, overexpression of PRB leads to. 4. Extracellular vesicle-mediated cell–cell communication in multiple myeloma. MM is a blood cancer formed by malignant plasma cells that create tumour masses in bone.

In contrast to leukaemia, the tumour masses are predominantly located in the bone marrow. Therefore, cell–cell communication in the BME has a key role in the pathogenesis of MM. The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors.

The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and.

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

Cell - Cell - Cell division and growth: In unicellular organisms, cell division is the means of reproduction; in multicellular organisms, it is the means of tissue growth and maintenance. Survival of the eukaryotes depends upon interactions between many cell types, and it is essential that a balanced distribution of types be maintained.

This is achieved by the highly regulated process of cell. Cell Growth and Division; Cellular Differentiation; The Tissue Level of Organization. Introduction; Types of Tissues; Epithelial Tissue; Connective Tissue Supports and Protects; Muscle Tissue and Motion; Nervous Tissue Mediates Perception and Response; Tissue Injury and Aging; The Integumentary System.

Introduction; Layers of the Skin. Neoplastic cells have fewer gap junctions Growth stimuli inhibit GJIC Carcinogens Oncogenes Growth Factors Growth inhibitors stimulate GJIC Cell cycle-related changes in GJIC Involvement of GJIC in the growth inhibition of neoplastic cells by nontransformed cells Specific disruption and.

The ongoing analysis and targeting of EV-mediated intercellular communication pathways can be viewed as a new therapeutic paradigm in cancer, while the analysis of oncogenic cargo contained in EVs released from cancer cells into biofluids is being developed for clinical use as a biomarker and companion diagnostics.

From the Back Cover. This book comprises a number of state-or-the-art reviews written by leading scientists. Each chapter gives a concise overview of specific intra- and intercellular events which regulate the proliferation of neoplastic cells, and the established or potential clinical implications of.

The book i read was by Lois Sakany, Cell Regulation: Understanding How Cell Functions, Growth and Division are regulated. This book was an overall 7 in my personal opinion, i liked a lot of this book and disliked a good amount for different reasons, one of the reasons why i liked this book was because it was an easy read i would pertain the Reviews: 1.

Macrophage-conditioned media and IGF-1 stimulated lung tumor cell growth in an additive manner, while EGF had no effect. Macrophage-derived factors increased p-Erk1/2, p-Akt and cyclin D1 levels in neoplastic cells, and the combined inhibition of both MEK and PI3K ablated macrophage-mediated increases in epithelial growth.

Cell - Cell - Intercellular communication: Formation of a multicellular organism starts with a small collection of similar cells in an embryo and proceeds by continuous cell division and specialization to produce an entire community of cooperating cells, each with its own role in the life of the organism.

Through cell cooperation, the organism becomes much more than the sum of its component parts. Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies.

In biology, cell signaling (cell signalling in British English) or cell-cell communication, governs the basic activities of cells and coordinates multiple-cell actions.

A signal is an entity that codes or conveys ical processes are complex molecular interactions that involve a lot of signals.

The ability of cells to perceive and correctly respond to their microenvironment is. The Biology of Normal and Neoplastic Stem Cells in CML in chronic phase CML based on reduced leukemic stem cell self-renewal potential coupled to partial autonomy from normal growth control mechanisms.

the availability of methods for quantitating and differentially manipulating very primitive leukemic and normal cells from patients with.

Normal and metastatic cells continuously exchange information with the surrounding tissue environment, and this communication governs many aspects of cell behavior. In particular, the physical placement or adhesions of cells within their environment are increasingly understood to facilitate this communication.

Cellular communication is an umbrella term used in biology and more in depth in biophysics, biochemistry and biosemiotics to identify different types of communication methods between living cellulites.

Some of the methods include cell signaling among others. This process allows millions of cells to communicate and work together to perform important bodily processes that are necessary for survival. Regulation Of Cell Growth Pathway Bioinformatics Disease and disorder research has been conducted in relation to the Regulation Of Cell Growth Pathway and Neoplasms, Malignant Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Malignant Paraganglionic Neoplasm.

These cells are relatively easy to obtain from total bone marrow cells by culturing under the influence of IL-3 or stem cell factor (SCF). After 3 to 4 weeks in culture, a nearly homogenous cell population of toluidine blue-positive cells are often obtained.

However, the question is how relevant equivalents these cells are to normal tissue MCs.Upregulation and maintenance of gap junctional communication in lens cells.

Exp. Eye Crossref, Medline, Google Scholar; Boswell B. A., Lein P. J., Musil L. S. (). Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol.Such mutant cells undergo clonal expansion and evolution into cancer cells via cell-cell communication between mutant cells and surrounding normal cells.

Drosophila is the only genetically tractable model animal that we can use to systematically study such oncogenic cell-cell communication at the organismal level.

This is enabling us to.